Platypnea-Orthodeoxia Syndrome after SARS-CoV-2 interstitial pneumonia: an overview and an update on our patient

Platypnea-Orthodeoxia Syndrome after SARS-CoV-2 interstitial pneumonia: an overview and an update on our patient


  • Nicola Zanoni
  • Chiara Longo a:1:{s:5:"en_US";s:26:"University Hospital Parma.";}
  • Annalisa Frizzelli
  • Francesco Longo
  • Rocco Accogli
  • Alfredo Antonio Chetta


Platypnea-Orthodeoxia Syndrome, Platypnea, Orthodeoxia, POS, Pulmonary Fibrosis, SARS-CoV-2


Platypnea-Orthodeoxia Syndrome (POS) is a clinical entity defined as positional dyspnoea (platypnea) and arterial desaturation (orthodeoxia) that occurs when sitting or standing up and usually resolves by lying down. Up to April 25th 2021, eleven cases of POS after SARS-CoV-2 pneumonia have been reported on Pubmed. Accordingly, SARS-CoV-2 infection may be considered as an emergent cause of POS due to an increase in ventilation/perfusion (V/Q) mismatch. In this article we provide an update on the patient with POS after fibrotic evolution of SARS-CoV-2 interstitial pneumonia, which we previously reported and we discuss the case reports of POS due to SARS-CoV-2 infection.


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How to Cite

Zanoni N, Longo C, Frizzelli A, Longo F, Accogli R, Chetta AA. Platypnea-Orthodeoxia Syndrome after SARS-CoV-2 interstitial pneumonia: an overview and an update on our patient. Acta Biomed [Internet]. 2022 Mar. 14 [cited 2024 Jul. 21];93(1):e2022015. Available from: