Phlegmasia cerulea dolens superimposed on disseminated intravascular coagulation in COVID-19. Phlegmasia and disseminated intravascular coagulation in COVID-19.

Main Article Content

Daniele Orso
Lisa Mattuzzi
Sara Scapol
Silvia Delrio
Luigi Vetrugno
Tiziana Bove

Keywords

Phlegmasia cerulea dolens; disseminated intravascular coagulation; COVI-19.

Abstract

COVID-19 infection has several cardiovascular implications, and coagulopathy is a common abnormality in these patients, often coupled with elevated plasma fibrinogen and D-dimer levels, contributing to adverse outcomes. Phlegmasia cerulea dolens (PCD) is a rare manifestation of deep vein thrombosis. It is life-threatening and can rapidly lead to venous gangrene of the extremity. Only a few cases of COVID-19 associated with PCD are reported in the literature, despite thromboembolism being the common paradigm between the two diseases. We present the case of a 64-year-old adult with acute severe COVID-19 pneumonia who developed PCD despite constantly elevated activated partial thromboplastin time and international normalized ratio.

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