Oncologic outcomes of salvage high-intensity focused ultrasound (HIFU) in radiorecurrent prostate cancer. A systematic review.

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Umberto Maestroni
Alessandro Tafuri
Francesco Dinale
Davide Campobasso
Alessandro Antonelli
Francesco Ziglioli


High-Intensity Focused Ultrasound, Hifu, Salvage Hifu, prostate cancer, cancer recurrence, radiotherapy, EBRT, minimally-invasive technique


INTRODUCTION. External Beam Radiation Therapy (EBRT) is one of the option available for the treatment of clinically localized prostate cancer. In patients with radiorecurrent localized prostate cancer, Androgen Deprivation Therapy (ADT) is one of the most common therapeutic strategy. However, in the last decades, other salvage treatment options have been investigated, such as brachytherapy, cryoablation and High Intensity Focused Ultrasound (Hifu).

MATERIAL AND METHODS. The oncologic outcome of Hifu in a salvage setting after EBRT failure was investigated. We reviewed the literature from 2005 to 2020 in order to report the oncologic outcome of the technique.

RESULTS. A total of 1241 patients were analyzed, with a mean age of  68.6 years and a PSA value of 5.87 ng/mL before treatment. Mean follow-up was 24.3 months after treatment, ranging from 3 to 168 months.

CONCLUSION. Our review of the literature revealed that salvage Hifu is effective in the treatment of radiorecurrent clinically localized prostate cancer, with an overall survival of 85.2% at 5 years.


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