Intraventricular hemorrhage in preterm newborn: Predictors of mortality

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Benedetta Piccolo
Mariacristina Marchignoli
Francesco Pisani


Intraventricular haemorrhage, preterm infants, mortality


Background and aim: Intraventricular haemorrhage (IVH) is a cause of morbidity and mortality in preterm infants. It occurs primarily in preterm newborns with an incidence of about 20% and, despite the evolution of neonatal care that allows more and better survival, continues to be a cause of morbidity and mortality in all intensive care units. Our research aimed to evaluate the independent risk factors of mortality and the relative odds ratio for each degree of IVH.

Methods: In this retrospective study were included 96 preterm infants, born between 23^ and 36^ weeks of gestational age, which developed IVH of degree two-three-four diagnosed by means of cranial ultrasound. It was made a comparison within the sample by distinguishing the group with IVH degree two from degrees three and four.

Results: IVH of degree three and four was independently associated with mortality. We found a higher number of deaths in the GAs <= 26 weeks (p <0.01), which was also an independent predictor of mortality.

Conclusion: With this study it was further highlighted the high mortality of patients with an elevated degrees of IVH and low birth weight and early gestational age. These data, of important clinical relevance, oblige us to find new therapeutic strategies aimed at reducing the serious consequences of that disease.


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