Inflammatory bowel disease and infertility: analysis of literature and future perspectives
Keywords:
IBD, infertility, pregnancy, Chron's disease, ulcerative colitis, male infertility, female infertilityAbstract
Background: inflammatory bowel diseases (IBD) are chronic disorders that affect the gastrointestinal tract but which also present extraintestinal manifestations. One of the problems related to IBD is the presence of both female and male infertility.
Aim: determine the correlation between IBD and male and female infertility by analyzing the literature.
Material and methods: Studies carried out in the last twenty years have been selected through the pubmed search engine. Only studies were selected that in their conclusions showed a real correlation between IBD and infertility.
Results: the first cause of infertility in both sexes is related to the surgical interventions that patients have to face during the course of the disease, but there are also psychological causes or causes related to the use of drugs used for therapy.
Conclusions: further studies are needed to understand what are the real mechanisms underlying infertility in subjects suffering from IBD.
References
2) Mazzola M, Carini F, Damiani P, et al. Inflammatory bowel disease and colorectal cancer, nutraceutical aspects. Euromediterranean Biomedical Journal, 2016, 11. 123-129.
3) Carini F, Gagliardo C, Mazzola M, et al. Immunological aspects of crohn's disease: a regulatory function of tim-3/ galectin-9 in lyth1. Euromediterranean Biomedical Journal, 2017. 201712. 66-68.
4) Mazzola M, Carini F, Leone A, et al. Ibd, malignancy and oral microbiota: analysis of the literature. International Journal of Clinical Dentistry, 2016. 9, 273-278.
5) Cappello F, Mazzola M, Jurjus A, et al. Hsp60 as a Novel Target in IBD Management: A Prospect. Front Pharmacol. 2019 Feb 8;10:26.
6) Bonthala N, Kane S. Updates on Women's Health Issues in Patients with Inflammatory Bowel Disease. Curr Treat Options Gastroenterol. 2018 Mar;16(1):86-100.
7) Palomba S, Sereni G, Falbo A, Beltrami M, et al. Inflammatory bowel diseases and human reproduction: a comprehensive evidence-based review. World J Gastroenterol. 2014 Jun 21;20(23):7123-36.
8) Mountifield, R., Bampton, P., Prosser, R., Muller, K., & Andrews, J. M. Fear and fertility in inflammatory bowel disease: A mismatch of perception and reality affects family planning decisions. Inflammatory Bowel Diseases, 2009. 15(5), 720–725.
9) Selinger CP, Eaden J, Selby W, et al. Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative views. J Crohns Colitis. 2013 Jul;7(6):e206-13.
10) Cornish JA, Tan E, Teare J, et al. The effect of restorative proctocolectomy on sexual function, urinary function, fertility, pregnancy and delivery: a systematic review. Dis Colon Rectum. 2007 Aug;50(8):1128-38.
11) Bortoli A, Pedersen N, Duricova D, et al. Pregnancy outcome in inflammatory bowel disease: prospective European case control ECCO-EpiCom study, 2003-2006. Aliment Pharmacol Ther 2011; 34: 724-734
12) Riis L, Vind I, Politi P, et al. Does pregnancy change the disease course? A study in a European cohort of patients with inflammatory bowel disease. Am J Gastroenterol 2006; 101: 1539-1545
13) Munkholm P. Pregnancy, fertility, and disease course in patients with Crohn’s disease and ulcerative colitis. Eur J Intern Med 2000; 11: 215-221
14) Kane S, Kisiel J, Shih L, Hanauer S. HLA disparity determines disease activity through pregnancy in women with inflammatory bowel disease. Am J Gastroenterol 2004; 99: 1523-1526
15) Fukushima T, Hamada Y, Komiyama M, Matsuno Y, Mori C, Horii I. Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine. Reprod Toxicol 2007; 23: 153-157
16) Alonso V, Linares V, Bellés M, Albina ML, Sirvent JJ, Domingo JL, Sánchez DJ. Sulfasalazine induced oxidative stress: a possible mechanism of male infertility. Reprod Toxicol 2009; 27: 35-40
17) Shin, T., & Okada, H. Infertility in men with inflammatory bowel disease. World journal of gastrointestinal pharmacology and therapeutics, 2016. 7(3), 361–369.
18) Gorgun E, Remzi FH, Montague DK, Connor JT, O’Brien K, Loparo B, Fazio VW. Male sexual function improves after ileal pouch anal anastomosis. Colorectal Dis 2005; 7: 545-550
Downloads
Published
Issue
Section
License
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.
How to Cite
