Not all is COVID19: a case of eclampsia and posterior reversible encephalopathy syndrome in the emergency room.

Not all is COVID19: a case of eclampsia and posterior reversible encephalopathy syndrome in the emergency room.

Authors

  • Erika Poggiali Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy
  • Nicola Morelli Ospedale Guglielmo da Saliceto, Neurology Department, Piacenza, Italy
  • Chiara Terracciano Ospedale Guglielmo da Saliceto, Neurology Department, Piacenza, Italy
  • Guglielmo Minervino Ospedale Guglielmo da Saliceto, Gynecologic and Obstretic Unit, Piacenza, Italy
  • Emanuela Contardi Ospedale Guglielmo da Saliceto, Gynecologic and Obstretic Unit, Piacenza, Italy
  • Domenica Zaino Ospedale Guglielmo da Saliceto, Neurology Department, Piacenza, Italy
  • Andrea Vercelli Ospedale Guglielmo da Saliceto, Emergency Department, Piacenza, Italy
  • Andrea Magnacavallo Ospedale Guglielmo da Saliceto, Emergency Department, Piacenza, Italy

Keywords:

eclampsia, pregnancy complication, brain edema, posterior reversible encephalopathy syndrome, cerebral vasospasm, COVID19, SARS-CoV-2.

Abstract

In the so called COVID19 era, headache, fever and gastrointestinal symptoms are highly suggestive for SARS-CoV-2 infection, but in all the cases presenting to the emergency room, clinicians should always keep in mind alternative diagnoses, particularly if the patient is pregnant.  Life-threatening diseases, such as eclampsia and posterior reversible encephalopathy syndrome (PRES), should be promptly recognized and treated. Eclampsia is defined as a seizure occurring in association with pre-eclampsia, and it represents one of the major and serious obstetric disorders associated with significant maternal and perinatal morbidity and mortality. PRES is a distinctive clinical and imaging syndrome characterized by acute headaches, visual impairment, seizures, and altered sensorium, that can be associated with severe eclampsia. Emergency clinicians should always consider eclampsia in the differential diagnosis of headache in pregnant women. The prompt and accurate diagnosis of eclampsia/PRES is crucial to prevent adverse maternal and perinatal outcomes. Here we describe the case of a young pregnant woman admitted to our emergency department for fever, dyspnea, headache, nausea and vomiting, who developed generalized tonic clonic seizures and a subsequent status epilepticus due to eclampsia and PRES.

References

1. The Eclampsia Trial Collaborative Group. Which anticonvulsant for women with eclampsia? Evidence from the collaborative eclampsia trial. Lancet. 1995; 345:1455–63.
2. Pearce CF, Hansen WF. Headache and neurological disease in pregnancy. Clin Obstet Gynecol. 2012; 55(3):810–828. doi: 10.1097/GRF.0b013e31825d7b68.
3. American College of Obstetricians and Gynecologists. Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013; 122:1122–31.
4. Lindheimer MD, Taler SJ, Cunningham FG. ASH position paper: hypertension in pregnancy. J Clin Hypertens (Greenwich). 2009; 11(4):214- 225.
5. Munro PT. Management of eclampsia in the accident and emergency department. J Accid Emerg Med. 2000; 17(1):7-11. doi: 10.1136/emj.17.1.7.
6. Karumanchi SA, Lindheimer MD. Advances in the understanding of eclampsia. Curr Hypertens Rep. 2008; 10(4):305-12. doi: 10.1007/s11906-008-0057-3.
7. Sibai BM, Stella CL. Diagnosis and management of atypical preeclampsia-eclampsia. Am J Obstet Gynecol. 2009; 200(5): 481.e1-7. doi: 10.1016/j.ajog.2008.07.048. Epub 2008 Nov 18.
8. Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2013; 170:1–7.
9. Say L, Chou D, Gemmill A, Tuncalp O, Moller AB, € Daniels J, et al. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014; 2:e323–33.
10. Baha M Sibai. Diagnosis, prevention, and management of eclampsia. Obstet Gynecol. 2005; 105(2):402-10. doi: 10.1097/01.AOG.0000152351.13671.99.
11. Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J, et al. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie trial: a randomised placebo-controlled trial. Lancet. 2002; 359:1877–90. 16.
12. Poggiali E, Vercelli A, Cillis MG, Ioannilli E, Iannicelli T, Magnacavallo A. Triage decision-making at the time of COVID-19 infection: the Piacenza strategy. Intern Emerg Med. 2020;15(5):879-882. doi: 10.1007/s11739-020-02350-y.
13. Copetti R, Soldati G, Copetti R. Chest sonography: a useful tool to differentiate acute cardiogenic pulmonary edema from acute respiratory distress syndrome. Cardiovascular Ultrasound. 2008; 6:16.
14. Poggiali E, Bastoni D, Ioannilli E, Vercelli A, Magnacavallo A. Deep Vein Thrombosis and Pulmonary Embolism: Two Complications of COVID-19 Pneumonia? Eur J Case Rep Intern Med. 2020; 7(5):001646. doi: 10.12890/2020_001646. eCollection 2020.
15. Luciano Gattinoni, Davide Chiumello, Sandra Rossi. COVID-19 pneumonia: ARDS or not? Crit Care. 2020; 24: 154. Published online 2020 Apr 16. doi: 10.1186/s13054-020-02880-z.
16. J O Donaldson. Eclamptic hypertensive encephalopathy. Semin Neurol. 1988; 8(3):230-3. doi: 10.1055/s-2008-1041383.
17. Brewer J, Owens MY, Wallace K, Reeves AA, Morris R, Khan M, lamarca B, Martin JN., Jr Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia. Am J Obstet Gynecol. 2013; 208(6): 468.e1–468.e6. doi: 10.1016/j.ajog.2013.02.015.
18. Mayama M, Uno K, Tano S, Yoshihara M, Ukai M, Kishigami Y, et al. Incidence of posterior reversible encephalopathy syndrome in eclamptic and patients with preeclampsia with neurologic symptoms. Am J Obstet Gynecol 2016; 215:239.e1-5.
19. Morelli N, Gori S, Michelassi MC, Falorni M, Cafforio G, Bianchi MC, Cosottini M, Orlandi G, Murri L, Tartaglione A. Atypical posterior reversible encephalopathy syndrome in puerperium. Eur Neurol. 2008; 59(3-4):195-7. doi: 10.1159/000114044. Epub 2008 Jan 29.
20. Bartynski WS. Posterior reversible encephalopathy syndrome, part 1: fundamental imaging and clinical features. AJNR Am J Neuroradiol. 2008; 29(6):1036-1042.
21. Granata G, Greco A, Iannella G, Granata M, Manno A, Savastano E, et al. Posterior reversible encephalopathy syndrome—insight into pathogenesis, clinical variants and treatment approaches. Autoimmun Rev 2015; 14:830-6.
22. Fugate JE, Rabinstein AA. Posterior reversible encephalopathy syndrome: Clinical and radiological manifestations, pathophysiology, and outstanding questions. Lancet Neurol 2015; 14:914-259.
23. Thomas SV. Neurological aspects of eclampsia. J Neurol Sci. 1998; 155(1):37-43. doi: 10.1016/s0022-510x(97)00274-8, Kaplan PW. Neurologic aspects of eclampsia. Neurol Clin. 2004; 22(4):841-61. doi: 10.1016/j.ncl.2004.07.005.
24. Camara-Lemarroy CR, Escobedo-Zúñiga N, Villarreal-Garza E, García-Valadez E, Góngora-Rivera F, Villarreal-Velázquez HJ.Posterior reversible leukoencephalopathy syndrome (PRES) associated with severe eclampsia: Clinical and biochemical features. Pregnancy Hypertens. 2017; 7:44-49. doi: 10.1016/j.preghy.2017.01.003. Epub 2017 Jan 16.
25. Shankar J, Banfield J. Posterior Reversible Encephalopathy Syndrome: A Review. Can Assoc Radiol J. 2017; 68(2):147-153. doi: 10.1016/j.carj.2016.08.005. Epub 2017 Jan 26.
26. Lee VH, Wijdicks EF, Manno EM, Rabinstein AA. Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol. 2008; 65(2):205–210.
27. TG Liman, G. Bohner, PU Heuschmann, M Scheel, M Endres, E Siebert. Clinical and radiological differences in posterior reversible encephalopathy syndrome between patients with preeclampsia‐eclampsia and other predisposing diseases. Eur J Neurol. 2012; 19(7):935-43. doi: 10.1111/j.1468-1331.2011.03629.x
28. Lew M, Klonis E. Emergency management of eclampsia and severe pre-eclampsia. Emerg Med (Fremantle). 2003; 15(4):361-8. doi: 10.1046/j.1442-2026.2003.00475.x
29. Wagner SJ, Acquah LA, Lindell EP, Craici IM, Wingo MT, Rose CH, White WM, August P, Garovic VD. Posterior reversible encephalopathy syndrome and eclampsia: pressing the case for more aggressive blood pressure control. Mayo Clin Proc. 2011; 86(9):851-6. doi: 10.4065/mcp.2011.0090.
30. Negro A, Delaruelle Z, Ivanova TA, Khan S, Ornello R, Raffaelli B, Terrin A, Reuter U, Mitsikostas DD; European Headache Federation School of Advanced Studies (EHF-SAS). Headache and pregnancy: a systematic review. J Headache Pain. 2017; 18(1):106. doi: 10.1186/s10194-017-0816-0.

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Published

04-11-2021

Issue

Section

Case Reports: General Surgery and Miscellanea

How to Cite

1.
Poggiali E, Morelli N, Terracciano C, Minervino G, Contardi E, Zaino D, et al. Not all is COVID19: a case of eclampsia and posterior reversible encephalopathy syndrome in the emergency room. Acta Biomed [Internet]. 2021 Nov. 4 [cited 2024 Jul. 18];92(S1):e2021117. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/11017