COVID-19 and NF-kB: The Hepcidin paradox and the Iron Storm

Main Article Content

Filippo Banchini

Keywords

Hepcidin, NTBI, ferritin, ards

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
Abstract 15 |

References

1) Nairz M, Theurl I, Swirski FK, Weiss G. "Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels. Pflugers Arch. 2017 Apr;469(3-4):397-418. doi: 10.1007/s00424-017-1944-8. Epub 2017 Mar 1. PMID: 28251312; PMCID: PMC5362662.3
2) Zhang V, Nemeth E, Kim A. Iron in Lung Pathology. Pharmaceuticals (Basel). 2019 Feb 15;12(1):30. doi: 10.3390/ph12010030. PMID: 30781366; PMCID: PMC6469192
3) Kim J, Wessling-Resnick M. The Role of Iron Metabolism in Lung Inflammation and Injury. J Allergy Ther. 2012;3(Suppl 4):004. doi: 10.4172/2155-6121.S4-004. Epub 2012 Jan 25. PMID: 29226014; PMCID: PMC5718378.
4) Hirano T, Murakami M. COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome. Immunity. 2020 May 19;52(5):731-733. doi: 10.1016/j.immuni.2020.04.003. Epub 2020 Apr 22. PMID: 32325025; PMCID: PMC7175868.
5) Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, et al. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem. 2003 May 16;278(20):17646-54. doi: 10.1074/jbc.M210905200. Epub 2003 Mar 11. PMID: 12637578
6) Liao RX, Sun JG, Zhong XL, Zhou JX, Wang YZ. [Experimental study on transcription regulation of mouse hepcidin gene by NF-kB]. Zhonghua Gan Zang Bing Za Zhi. 2006 Feb;14(2):118-23. Chinese. PMID: 16494782.
7) Kobune M, Kohgo Y, Kato J, Miyazaki E, Niitsu Y. Interleukin-6 enhances hepatic transferrin uptake and ferritin expression in rats. Hepatology. 1994 Jun;19(6):1468-75. PMID: 8188178.
8) Tao N, Li K, Liu J. Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease. Oxid Med Cell Longev. 2020 Jun 26;2020:9547127. doi: 10.1155/2020/9547127. PMID: 32685102; PMCID: PMC7338975.
9) Kell DB, Pretorius E. Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. Metallomics. 2014 Apr;6(4):748-73. doi: 10.1039/c3mt00347g. PMID: 24549403.
10) Zhao J, He S, Minassian A, Li J, Feng P. Recent advances on viral manipulation of NF-κB signaling pathway. Curr Opin Virol. 2015 Dec;15:103-11. doi: 10.1016/j.coviro.2015.08.013. Epub 2015 Sep 15. PMID: 26385424; PMCID: PMC4688235
11) Santoro MG, Rossi A, Amici C. NF-kappaB and virus infection: who controls whom. EMBO J. 2003 Jun 2;22(11):2552-60. doi: 10.1093/emboj/cdg267. PMID: 12773372; PMCID: PMC156764