Respiratory infections in allergic children: the preventive role of a multicomponent nutraceutical
Keywords:
respiratory infection, antibiotics, allergic rhinoconjunctivitis, children, nutraceuticalAbstract
Allergic children with respiratory infections (RI) are a demanding challenge for the paediatrician. Antibiotic prescription represents a critical problem, mainly concerning the growing issue of resistance. To prevent RI would be therefore a goal in clinical practice. In this regard, modulation of immune system may have a critical role. The aim of the present study was to measure the number of respiratory infections and the use of antibiotics in two groups of children suffering from allergic rhinoconjunctivitis. The first group took a course of a nutraceutical (Lertal®) before the observation (active group, AG); a second one was considered as control (control group, CG). The children were visited at baseline and after 1 year. The number of RI and of antibiotic courses was the primary outcomes. Children in AG reported a significant reduced number of RI and of antibiotic course in comparison with CG (p=0.01 and 0.002 respectively). In conclusion, the current study showed that a course with a multicomponent nutraceutical could reduce the number of respiratory infections and consequently the use of antibiotics in children with allergic rhinoconjunctivitis.
References
2. Cazzola M, Anaupurapu S, Page CP. Polyvalent mechanical bacterial lysate for the prevention of recurrent respiratory infections: a meta-analysis. Pulm Pharmacol Ther 2011; 25:62-8
3. Ciprandi G, Tosca MA, Fasce L. Allergic children have more numerous and severe respiratory infections than non-allergic children. Ped Allergy Immunol 2006; 17: 389–91
4. Cirillo I, Marseglia GL, Klersy C, Ciprandi G Allergic patients have more numerous and prolonged respiratory infections than non-allergic subjects. Allergy 2007;62(9):1087-90
5. Ciprandi G., Buscaglia S., Pesce G.P., Pronzato C., Ricca V., Parmiani S., et al. Minimal persistent inflammation is present at mucosal level in asymptomatic rhinitic patients with allergy due to mites. J Allergy Clin Immunol 1995; 96:971-9
6. Li J, Song X, Yang T, Chen Y, Gong Y, Yin X, Lu Z. A Systematic Review of Antibiotic Prescription Associated With Upper Respiratory Tract Infections in China. Medicine (Baltimore). 2016;95(19):e3587
7. Alexandrino AS, Santos R, Melo C, Bastos JM, Postiaux G. Caregivers' education vs rhinopharyngeal clearance in children with upper respiratory infections: impact on children's health outcomes. Eur J Pediatr. 2017;176(10):1375-1383
8. Esposito S, Soto-Martinez ME, Feleszko W, Jones MH, Shen KL, Schaad UB. Nonspecific immunomodulators for recurrent respiratory tract infections, wheezing and asthma in children: a systematic review of mechanistic and clinical evidence. Curr Opin Allergy Clin Immunol 2018;18:198-209
9. Ciprandi G, Tosca MA, Passalaqua G, Canonica W. Longterm cetirizine treatment reduces allergic symptoms and supplemental medication use in children with mite allergy Ann Allergy Asthma 2001;87:222-6
10. Ciprandi G, Sormani MP, Cirillo I, Tosca MA. Upper respiratory infections and SLIT: preliminary evidence. Annals Allergy 2009; 102:262-3
11. Marseglia GL, Licari A, Ciprandi G. A polycentric, randomized, double blind, parallel-group, placebo-controlled study on Lertal®, a multicomponent nutraceutical, as add-on treatment in children with allergic rhinoconjunctivitis: Phase I during active treatment. J Biol Reg 2019;33:617-622
12. Marseglia GL, Licari A, Leonardi S, Papale M, Zicari AM, Schiavi L, et al. A polycentric, randomized, parallel-group, study on Lertal®, a multicomponent nutraceutical, as preventive treatment in children with allergic rhinoconjunctivitis: Phase II. Ital J Ped 2019;45:84
13. Brożek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. 2017;140(4):950-958
14. Schroeck JL, Ruh CA, Sellick JA Jr, et al. Factors associated with antibiotic misuse in outpatient treatment for upper respiratory tract infections. Antimicrob Agents Chemother 2015; 59:3848–3852
15. Toivonen L, Karppinen S, Schuez-Havupalo L, et al. Burden of recurrent respiratory tract infections in children: a prospective cohort study. Pediatr Infect Dis J 2016; 35:e362 – e369
16. Simon AK, Hollander GA, McMichael A. Evolution of the immune system in humans from infancy to old age. Proc Biol Sci 2015; 282:2014308
17. Yepes-Nunes JJ, Brozek JL, Fiocchi A, Pawankar R, Cuello-Garcia C, Zhang Y, et al. Vitamin D supplementation in primary allergy prevention: systematic review of randomized and non-randomized studies. Allergy 2018;73:37-49
18. Kim YH, Kim KW, Kim MJ, Sol IS, Yoon SH, Ahn HS, et al. Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis. Ped Allergy Immunol 2016;27:580-90
19. Aryan Z, Rezaei N, Camargo CA. Vitamin status, aeroallergen sensitization, and allergic rhinitis: a systematic review and meta-analysis. Int Rev Immunol 2017;36:41-53
20. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol. 2017;108(Pt B):375-391
21. Igarashi M, Miyazaki Y. A review on bioactivities of Perilla: progress in research on the functions of Perilla as medicine and food. Evid Based Complement Alternat Med 2013;2013:925342.
22. Chirumbolo S. The role of Quercetin, Flavonols and Flavones in modulating inflammatory cell function. Inflamm Allergy-Drug Targets 2010; 9(4):263-85.
Mlcek J, Jurikova T, Skrovankova S, Sochor J. Quercetin and its anti-allergic immune response. Molecules 2016;21,623
Downloads
Published
Issue
Section
License
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.