Congenital Bleeding Disorders amid the COVID-19 pandemic: Open questions and recommendations

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Majid Naderi
Fatemeh Malek
Ghasem Miri Aliabad
Mahammad Behnampoor
Mehran Karimi
Vincenzo De Sanctis


COVID-19, congenital bleeding disorders, treatment, surveillance


This article reviews the current knowledges of congenital bleeding disorders (CBD) amid the COVID-19 pandemic. It appears that CBD is not associated with higher risk of getting COVID-19 and so the prevalence of COVID-19 among them seems not higher compared to the general population. In absence of specific therapeutic recommendations, it is essential to make a correct assessment of the risk of haemorrhage/thrombosis. Based on expert opinion, strategies for outpatient management include adherence to prescribed regimens, telemedicine, and communication about COVID-19 in patients with CBD. More data should be also collected to better characterize the impact of COVID-19 on patients with CBD. The current findings encourage further studies to determine the prevalence of SARS-CoV2 infection in CBD patients to understand more fully the burden of this novel pathogen and to develop adequate preventive measures against this infection.



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