Congenital Bleeding Disorders amid the COVID-19 pandemic: Open questions and recommendations

Main Article Content

Majid Naderi
Fatemeh Malek
Ghasem Miri Aliabad
Mahammad Behnampoor
Mehran Karimi
Vincenzo De Sanctis

Keywords

COVID-19, congenital bleeding disorders, treatment, surveillance

Abstract

This article reviews the current knowledges of congenital bleeding disorders (CBD) amid the COVID-19 pandemic. It appears that CBD is not associated with higher risk of getting COVID-19 and so the prevalence of COVID-19 among them seems not higher compared to the general population. In absence of specific therapeutic recommendations, it is essential to make a correct assessment of the risk of haemorrhage/thrombosis. Based on expert opinion, strategies for outpatient management include adherence to prescribed regimens, telemedicine, and communication about COVID-19 in patients with CBD. More data should be also collected to better characterize the impact of COVID-19 on patients with CBD. The current findings encourage further studies to determine the prevalence of SARS-CoV2 infection in CBD patients to understand more fully the burden of this novel pathogen and to develop adequate preventive measures against this infection.

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References

1. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention [published online ahead of print, 2020 Feb 24]. JAMA. 2020;10.1001/ jama.2020. 2648. doi:10.1001/jama.2020.2648.
2. Leebeek FW, Eikenboom JC. Von Willebrand’s Disease. N Engl J Med. 2017;376:701-702.

3. Montgomery RR, Flood VH. What have we learned from large population studies of von Willebrand disease? Hematol Am Soc Hematol Educ Program. 2016; 2016:670-677.

4. Bowman ML, James PD. Controversies in the diagnosis of type 1 von Willebrand disease. Int J Lab Hematol. 2017;39 (Suppl 1):61-68.

5. Castaman G, Linari S. Diagnosis and treatment of von Willebrand disease and rare bleeding disorders. Clin Med. 2017;6: E45. doi: 10.3390/jcm6040045.

6. Montgomery RR, Flood VH. What have we learned from large population studies of von Willebrand disease? Hematol Am Soc Hematol Educ Program. 2016; 2016:670-677.

7. Neff AT. Current controversies in the diagnosis and management of von Willebrand disease. Ther Adv Hematol. 2015; 6:209-216.

8. Mahlangu JN, Gilham A. Guideline for haemophilia treatment in South Africa. S Afr Med J.
2008; 98:126-140.

9. Gresele P. Subcommittee on Platelet Physiology of the International Society on Thrombosis and
Hemostasis. Diagnosis of inherited platelet function disorders: Guidance from the SSC of the ISTH.
J Thromb Haemost. 2015; 13:314-322.

10. Kenny D, Mezzano D, Mumford AD, et al. Diagnosis of suspected inherited platelet function disorders: Results of a worldwide survey. J Thromb Haemost. 2014; 12:1562-1592.

11. Hayward CP, Rao AK, Cattaneo M. Congenital platelet disorders: Overview of their mechanisms,
diagnostic evaluation and treatment. Haemophilia. 2006; 12:128-136.

12. Dorgalaleh A, Dabbagh A, Tabibian S, et al. Patients with Congenital Bleeding Disorders Appear to be Less Severely Affected by SARS-CoV-2: Is Inherited Hypocoagulability Overcoming Acquired Hypercoagulability of Coronavirus Disease 2019 (COVID-19)? Semin Thromb Hemost. 2020;10.1055/s-0040-1713435.

13. Álvarez Román MT, Butta Coll N, García Barcenilla S, et al. Registry of patients with congenital bleeding and COVID-19 in Madrid. [published online ahead of print, 2020 Jun 10]. Haemophilia. 2020;10.1111/ hae.14089. doi:10.1111/hae.14089.

14. Thachil J, Tang N, Gando S, et al. ISTH interim guidance on recognition and management
of coagulopathy in COVID-19. J Thromb Haemost. 2020 March 25. doi:10.1111/jth.14810

15. Chen G, Wu D, Guo W, et al. Clinical and immunologic features in severe and moderate coronavirus disease 2019. J Clin Invest. 2020; 130:2620-2629.

16. Han H, Yang L, Liu R, et al. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clin Chem Lab Med. 2020; 58:1116–1120.

17. Xiong M, Liang X, Wei YD. Changes in blood coagulation in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis. Br J Haematol. 2020; 189:1050–1063.

18. Coppola A, Tagliaferri A, Rivolta GF, Quintavalle G, Franchini M. Confronting COVID-19: Issues in Hemophilia and Congenital Bleeding Disorders. Semin Thromb Hemost. 2020 Jun. DOI: 10.1055/s-0040-1712961.


19. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (London, England). 2020; 395:497-506.

20. Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020. [Epub ahead of print] . Doi: 10.1111/jth.14830.

21. Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020; S0049-3848(20)30120-1; [Epub ahead of print] . Doi: 10.1016/j.thromres.2020.04.013.

22. Dolhnikoff M, Duarte-Neto AN, de Almeida Monteiro RA, et al. Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19. J Thromb Haemost. 2020. [Epub ahead of print]. Doi: 10.1111/jth.14844.


23. Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up. J Am Coll Cardiol 2020; S0735-1097(20)35008-7. doi: 10.1016/j. jacc.2020.04.031.

24. Cui D, Zhang A, Liu A, Hu Q. Clinical findings in a patient with haemophilia A affected by COVID-19. Haemophilia 2020. [Epub ahead of print] . Doi: 10.1111/hae.14000

25. World Federation of Haemophilia. Specific risks of COVID-19 to the bleeding disorders community. Available at https://news. wfh.org/specific-risks-of-covid-19-to-the-bleeding-disorderscommunity/.
Accessed April 28, 2020.

26. Hemophilia, WFO. Specific Risks of COVID-19 to the Bleeding Disorders Community April 2, 2020: World Federation of Hemophilia 2020 [Available from https://news.wfh.org/specific-risks-of-covid-19-to-the-bleeding-disorders-community/.
27. Kulkarni R. Use of telehealth in the delivery of comprehensive care for patients with haemophilia and other inherited bleeding disorders. Haemophilia. 2018; 24: 33‐42.

28. Hermans C, Lambert C, Sogorb A, Wittebole X, Belkhir L, Yombi JC. In-hospital management of persons with haemophilia and COVID-19: practical guidance [published online ahead of print, 2020 May 8]. Haemophilia. 2020;10.1111/hae.14045. doi:10.1111/hae.14045

29. http://eahad.org/european-principles-of-care/

30. Mannucci PM. Hemophilia therapy: the future has begun. Haematologica. 2020; 105:545-553.

31. Bangalore S, Sharma A, Slotwiner A, et al. ST-Segment Elevation in Patients with Covid-19 - A Case Series. N Engl J Med. 2020; 382:2478-2480.

32. Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020; 18:1094-1099.

33. World Federation of Haemophilia. Specific risks of COVID-19 to the bleeding disorders community. Available at https://news.wfh.org/specific-risks-of-covid-19-to-the-bleeding-disorderscommunity/.
Accessed April 28, 2020.


34. Wichmann D, Sperhake JP, Lütgehetmann M, et al. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19 [published online ahead of print, 2020 May 6]. Ann Intern Med. 2020; M20-2003. doi:10.7326/M20-2003.