A comprehensive update of ICET-A Network on COVID-19 in thalassemias: what we know and where we stand

A comprehensive update of ICET-A Network on COVID-19 in thalassemias: what we know and where we stand

Authors

  • Vincenzo De Sanctis Quisisana Hospital, Ferrara
  • Duran Canatan Antalya Genetic Diseases Diagnostic Center, Antalya,Turkey
  • Joan Lluis Vives Corrons Red Blood Cell and Haematopoietic Disorders Unit, Institute for Leukaemia Research Josep Carreras (IJC) and University of Barcelona, Catalonia, Spain. ENERCA Coordinator
  • Mehran Karimi Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Shahina Daar Department of Haematology, College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman
  • Christos Kattamis First Department of Paediatrics, National Kapodistrian University of Athens, Athens, Greece
  • Ashraf T Soliman Pediatrics and Endocrinology Department of Pediatrics, Hamad Medical Center, Doha, Qatar and Department of Pediatrics, University of Alexandria, Alexandria, Egypt
  • Yasser Wali Paediatric Hematology Unit, Child Health Department, College of Medicine, Sultan Qaboos University Oman and Department of Paediatrics, Faculty of Medicine, Alexandria University, Egypt
  • Salam Alkindi Department of Haematology, College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman
  • Valeh Huseynov Center of Thalassemia, Baku, Azerbaijan
  • Afag Nasibova Center of Thalassemia, Baku, Azerbaijan
  • Tarık Onur Tiryaki 10 İstanbul University, Faculty of Medicine, Department of Hematology, İstanbul,Turkey
  • Melike Sezgin Evim Uludag University, Medical Faculty, Dept. of Pediatric Hematology, Bursa, Turkey
  • Adalet Meral Gunes Uludag University, Medical Faculty, Dept. of Pediatric Hematology, Bursa, Turkey
  • Zeynep Karakas Istanbul University, Istanbul Faculty of Medicine, Pediatric Hematology / Oncology, Istanbul, Turkey
  • Soteroula Christou Archibishop Makarios III Hospital, Thalassaemia Clinic, Nicosia, Cyprus
  • Mohamed A Yassin Hematology Section, National Center for Cancer Care and Research, Hamad Medical Corporation, (HMC), Doha, Qatar
  • Maria Concetta Galati Pediatric Haematoncology, Pugliese-Ciaccio Hospital, Catanzaro, Italy
  • Saveria Campisi UOSD Thalassemia, Umberto I° Hospital, Siracusa, Italy
  • Tahereh Zarei Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Doaa Khater Department of Pediatric Endocrinology Alexandria University, Egypt and Department of Pediatrics, Sultan Qaboos University, Oman, Qatar
  • Yesim Oymak Dr. Behcet Uz Children’s Hospital, Izmir, Turkey
  • Valeriya Kaleva Expert Center for Coagulopathies and Rare Anemias, Varna, Bulgaria
  • Denka Stoyanova Pediatric Hematoncology, University Hospital “Tzaritza Giovanna – ISUL”, Sofia, Bulgaria
  • Atanas Banchev Pediatric Hematoncology, University Hospital “Tzaritza Giovanna – ISUL”, Sofia, Bulgaria
  • Myrto Skafida First Department of Paediatrics, National Kapodistrian University of Athens, Athens, Greece
  • Yurdanur Kilinc Pediatric Hematology Department, Çukurova University, Adana, Turkey

Keywords:

COVID-19 pandemic, thalassemias, iron overload, associated co-morbidities, clinical outcome, update.

Abstract

A review of the literature on COVID-19 pandemic in patients with thalassemias is presented. Globally, the prevalence of COVID-19 among  β-thalassemia patients seems to be lower than in general population; associated co-morbidities aggravated the severity of  COVID- 19, leading to a poorer prognosis, irrespective of age. A multicenter registry will enhance the understanding of COVID-19 in these patients and will lead to more evidence-based management recommendations.

References

Galanello R, Origa R. Beta-thalassemia. Orphanet J Rare Dis. 2010;5:11. Published 2010 May 21. doi:10.1186/1750-1172-5-11.

De Sanctis V, Kattamis C, Canatan D, et al. β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. Mediterr J Hematol Infect Dis. 2017;9(1):e2017018. Published 2017 Feb 20. doi:10.4084/MJHID.2017.018.

Cappellini MD, Motta I. New therapeutic targets in transfusion-dependent and -independent thalassemia. Hematology Am Soc Hematol Educ Program. 2017;1:278‐283.

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease

(COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323:1239–1242.

Eleftheriou A. Thalassaemia & Sickle Cell Disease: Classification of Risk Groups & Other Considerations

Guidance for Patients, Parents & Healthcare Professionals. 14 May 2020.

Canatan D, De Sanctis V. The medical concerns of patients with thalassemias at the time of COVID-19 outbreak: The personal experience and the international recommendations. Acta Biomed. 2020;91:218‐221.

Karimi M, De Sanctis V. Implications of SARSr-CoV 2 infection in thalassemias: Do patients fall into the "high clinical risk" category?. Acta Biomed. 2020;91:50‐56.

Motta I, De Amicis MM, Pinto VM, et al. SARS-CoV-2 infection in beta thalassemia: preliminary data from the Italian experience [published online ahead of print, 2020 Apr 20]. Am J Hematol. 2020;10.1002/ ajh.25840. doi:10.1002/ajh.25840.

Karimi M, Haghpanah S, Azarkeivan A, et al. Prevalence and Mortality due to Outbreak of Novel Coronavirus Disease (COVID-19) in β-Thalassemias: The Nationwide Iranian Experience [published online ahead of print, 2020 Jun 2]. Br J Haematol. 2020;10.1111/bjh.16911.

De SanctisV, Canatan D, Vives Corrons JL, et al. Preliminary Data on COVID-19 in Patients with Hemoglobinopathies: A Multicentre ICET-A Study. Mediterr J Hematol Infect Dis. 2020 (accepted for publication).

Marhaeni W, Wijaya AB, Kusumaningtyas P, Mapianto RS. Thalassemic Child Presenting with Anosmia due to COVID-19 [published online ahead of print, 2020 Jun 9]. Indian J Pediatr. 2020;1. doi:10.1007/ s12098-020-03370-4.

Gane SB, Kelly C, Hopkins C. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome? Rhinology. 2020;58:194–196.

Mao L, Wang M, Chen S, et al. Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study. (February 24, 2020). Available at SSRN http://dx.doi.org/10.2139/ssrn.3544840.

Goncalves S, Goldstein BJ. Pathophysiology of olfactory disorders and potential treatment strategies. Curr Otorhinolaryngol Rep. 2016;4:115–121.

Xu H, Zhong L, Deng J, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020;12(1):8. Published 2020 Feb 24. doi:10.1038/s41368-020-0074-x.

Lee Y, Min P, Lee S, Kim SW. Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients. J Korean Med Sci. 2020;35(18):e174. Published 2020 May 11. doi:10.3346/jkms.2020.35.e174.

Thalassemia International Federation .The COVID–19 pandemic and haemoglobin disorders. A contribution of Thalassaemia International Federation to its global patients’ community. https://thalassaemia.org.cy/publications/tif-publications/a-tif-proposed-haemoglobinopathy-patient-pathway-during-the-covid-19-pandemic-2.

Vives Corrons JL, De Sanctis V. Rare Anaemias, Sickle-Cell Disease and COVID-19. Acta Biomed. 2020;91(2):216‐217. Published 2020 May 11. doi:10.23750/abm.v91i2.9532.

Taher AT, Bou-Fakhredin R, Kreidieh F, et al. Care of patients with hemoglobin disorders during the COVID-19 pandemic: An overview of recommendations [published online ahead of print, 2020 May 11]. Am J Hematol. 2020;10.1002/ajh.25857.

Chowdhury SF, Anwar S. Management of Hemoglobin Disorders During the COVID-19 Pandemic. Front. Med.2020;7:306.doi:10.3389/fmed.2020.00306.

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Published

07-09-2020

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Section

REVIEWS/FOCUS ON - SPECIAL COVID19

How to Cite

1.
A comprehensive update of ICET-A Network on COVID-19 in thalassemias: what we know and where we stand. Acta Biomed [Internet]. 2020 Sep. 7 [cited 2024 Mar. 29];91(3):e2020026. Available from: https://mattioli1885journals.com/index.php/actabiomedica/article/view/10063