The discovery of TNF-alpha: a historical perspective
Main Article Content
Keywords
tumor necrosis factor, cytokine, cancer treatment, TNF-alfa
Abstract
Tumor necrosis factor (TNF), also known as TNF-alpha (TNF-α), is a pleiotropic pro-inflammatory cytokine that exerts multiple biologic effects. The research journey into the role of TNF has been a roller- coaster ride filled with ups and downs and it is still ongoing. At its discovery, huge expectations were laid upon this cytokine going so far that the cloning of human TNF, which had been achieved and published in 1984, was examined in the general press around the globe, and its therapeutic potential in cancer treatment was welcomed as the opening of a new era in cancer treatment. Nevertheless, the first clinical studies did not yield the expected results and it seemed for a moment that the glory of TNF was ending. But the discovery of the pro-inflammatory effect of TNF changed the course of the research journey of this cytokine. TNF is a highly pleiotropic cytokine and accordingly, it plays a pivotal role in many physiological functions, and is involved in a wide variety of pathological conditions. TNF has become a major target in chronic inflammatory diseases, and its neutralization have delivered the first insights into the development of a novel category of pharmaceuticals, the “biological drugs”.
References
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3. Ruddle NH, Waksman BH. Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism. J Exp Med 1968; 128:1267-79.
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5. Aggarwal BB, Kohr WJ, Hass PE, et al. Human tumor necrosis factor. Production, purification, and characterization. J Biol Chem 1985; 260:2345-54.
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9. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001; 104:487-501.
10. Pennica D, Nedwin GE, Hayflick JS, et al. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature 1984; 312:724-729.
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16. Ware CF. Tumor Necrosis Factors. Encyclopedia of Cancer (Second Edition). Editor(s): Joseph R. Bertino. pp 475-89; 2002.
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18. Wang JL, Yin WJ, Zhou LY, et al. Risk of non-melanoma skin cancer for rheumatoid arthritis patients receiving TNF antagonist: a systematic review and meta-analysis. Clin Rheumatol 2020; 39:769-778.
19. de Lisle D. Traité sur le vice cancereux. Paris: Couturier fils. 1774.
20. Oelschlaeger TA. Bacteria as tumor therapeutics? Bioeng Bugs 2010; 1:146-7.
21. Busch W. VII. Verhandlungen artzlicher gesellschaften. Berl Klin Wochenschr 1868; 5:137-8.
22. Fehleisen V. VI. Ueber die zuchtung der erysipelkokken auf kunstlichem nahrboden und ihre uebertragbarkeit auf den menschen. Dtsch Med Wochenschr 1882; 8:553-4.
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25. Coley WB. Late results of the treatment of inoperable sarcoma by the mixed toxins of erysipelas and bacillus prodigiosus. Am J Med Sci 1906; 131:375–430.
26. Starnes CO. Coley's toxins in perspective. Nature 1992; 357:11-2.
27. Leech PN. Erysipelas and Prodigiosus toxins (Coley). JAMA 1934; 103:1067–9.
28. Nauts HC, Swift WE, Coley BL. The treatment of malignant tumors by bacterial toxins as developed by the late William B. Coley, M.D., reviewed in the light of modern research. Cancer Res 1946; 6:205-16.
29. Nauts HC, Fowler GA, Bogatko FH. A review of the influence of bacterial infection and bacterial products (Coley's toxins) on malignant tumors in man; a critical analysis of 30 inoperable cases treated by Coley's mixed toxins, in which diagnosis was confirmed by microscopic examination selected for special study. Acta Med Scand Suppl 1953; 276:1-103.
30. Gratia A, Linz R. Le phenomenene de Schwartzman dans le sarcome du cobaye. C R Soc Biol 1931; 108:427–8.
31. Shear MJ, Perrault A. Chemical treatment of tumors. IX. Reactions of mice with primary subcutaneous tumors to injection of a hemorrhage- producing bacterial polysaccharide. J Natl Cancer Inst1944; 44:461–76.
32. O’Malley WE, Achinstein B, Shear MJ. Action of bacterial polysaccharide on tumours. II. Damage of sarcoma 37 by serum of mice treated with serratia marcescens polysaccharide, and induced tolerance. J Natl Cancer Inst 1962; 29:1169–75.
33. Algire GH, Legallais FY, Anderson BF. Vascular reactions of normal and malignant tissues in vivo. V. The role of hypotension in the action of a bacterial polysaccharide on tumors. J Natl Cancer Inst 1952; 12:1279-95.
34. Green S, Carswell E, Old LJ, et al. "Mechanisms of endotoxin-induced tumor hemorrhagic necrosis," Proc Am Assoc Cancer Res 1974; 15:139.
35. Hibbs JB Jr, Lambert LH Jr, Remington JS. Control of carcinogenesis: a possible role for the activated macrophage. Science 1972; 177:998-1000.
36. Keller R. Cytostatic elimination of syngeneic rat tumor cells in vitro by nonspecifically activated macrophages. J Exp Med 1973; 138:625-44.
37. Kelker HC, Oppenheim JD, Stone-Wolff D, et al. Characterization of human tumor necrosis factor produced by peripheral blood monocytes and its separation from lymphotoxin. Int J Cancer 1985; 36:69-73.
38. Bringman TS, Aggarwal BB. Monoclonal antibodies to human tumor necrosis factors alpha and beta: application for affinity purification, immunoassays, and as structural probes. Hybridoma 1987; 6:489-507.
39. Engelmann H, Aderka D, Rubinstein M, Rotman D, Wallach D. A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity. J Biol Chem 1989; 264:11974-80.
40. Engelmann H, Novick D, Wallach D. Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors. J Biol Chem. 1990; 265:1531-6.
41. Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer 2009; 9:361-71.
42. Old LJ. Tumor necrosis factor (TNF). Science 1985; 230:630-2.
43. Helson L, Green S, Carswell E, Old LJ. Effect of tumour necrosis factor on cultured human melanoma cells. Nature 1975; 258:731-2.
44. Williamson BD, Carswell EA, Rubin BY, Prendergast JS, Old LJ. Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon. Proc Natl Acad Sci USA 1983; 80:5397-401.
45. Haranaka K, Satomi N, Sakurai A. Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and hetero-transplanted human tumors in nude mice. Int J Cancer 1984; 34:263-7.
46. Brouckaert PG, Leroux-Roels GG, Guisez Y, Tavernier J, Fiers W. In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-gamma, on a syngeneic murine melanoma. Int J Cancer 1986; 38:763-9.
47. Teng MN, Park BH, Koeppen HK, Tracey KJ, Fendly BM, Schreiber H. Long-term inhibition of tumor growth by tumor necrosis factor in the absence of cachexia or T-cell immunity. Proc Natl Acad Sci USA 1991; 88:3535-9.
48. Berendt MJ, North RJ, Kirstein DP. The immunological basis of endotoxin-induced tumor regression. Requirement for T-cell-mediated immunity. J Exp Med 1978; 148:1550-9.
49. Berendt MJ, North RJ, Kirstein DP. The immunological basis of endotoxin-induced tumor regression. Requirement for a pre-existing state of concomitant anti-tumor immunity. J Exp Med 1978; 148:1560-9.
50. McIntosh JK, Mulé JJ, Merino MJ, Rosenberg SA. Synergistic antitumor effects of immunotherapy with recombinant interleukin-2 and recombinant tumor necrosis factor-alpha. Cancer Res 1988; 48:4011-7.
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The discovery of TNF-alpha: a historical perspective. Med Histor [Internet]. 2023 Sep. 18 [cited 2024 Jun. 30];7(2):e2023037. Available from: https://mattioli1885journals.com/index.php/MedHistor/article/view/14925
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How to Cite
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The discovery of TNF-alpha: a historical perspective. Med Histor [Internet]. 2023 Sep. 18 [cited 2024 Jun. 30];7(2):e2023037. Available from: https://mattioli1885journals.com/index.php/MedHistor/article/view/14925