Spirometry, cardiopulmonary exercise testing and the six-minute walk test results in sarcoidosis patients

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Arda Kiani
Alireza Eslaminejad
Mohsen Shafeipour
Fatemeh Razavi
Seyyed Reza Seyyedi
Babak Sharif-Kashani
Habib Emami
Mehrdad Bakhshayesh-Karam
Atefeh Abedini


Respiratory function tests (D012129), Cardiopulmonary exercise testing (D005080), 6-minute walk test, Sarcoidosis (D012507), Spirometry (D013147


Background: The 6-minutes walking test, cardiopulmonary exercise testing, and spirometry are useful tools, for examination of the respiratory impairment and functional capacity in patients with lung diseases. Sarcoidosis is a multisystem granulomatous disease of unknown etiology.

Objectives: Since the pulmonary involvement can affect the quality of life in sarcoidosis patients, this study aimed to evaluate the aforementioned tests, in order to examine the functional capacity of sarcoidosis patients, in different stages.

Methods: This cross-sectional study carried out, on 50 Iranian patients with sarcoidosis. Patients were classified into three groups, based on the findings of the chest radiography, as well as the pulmonary CT scan, performed by an expert radiologist; pulmonary, cardiac and activity function have been evaluated in the patients, using cardiopulmonary exercise testing, 6-minutes walking test and spirometry.

Results: In cardiopulmonary exercise testing, percent-predicted peak VO2, 57.75±15.49, p<0.015 and percent-predicted O2 pulse, 70.54 ± 17.37, p<0.013 were significantly lower in third group, in comparison with other groups. On the other hand, VE/CO2 (AT) (34.99±5.67, p<0.000) was significantly higher in third group, in comparison with the other groups. Percent-predicted VO2 showed a strong positive correlation with age (r = 0.377; p=0.009), TSH (r = 0.404; p= 0.007) and percent-predicted FVC (r=0.443; p=0.002). In addition,  O2pulse showed a positive correlation with BMI (r =0.324; p=0.026), percent-predicted FVC (r = 0.557; p= 0.000) and percent-predicted FEV1 (r=0.316; p=0.032).

Conclusions: According to this study the ventilatory limitation, pulmonary involvement, and deconditioning are the main causes of activity limitations in sarcoidosis patients.

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