Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study

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Mickael Catinon
Catherine Cavalin
Cécile Chemarin
Stéphane Rio
Elisabeth Roux
Mathieu Pecquet
Anne-Sophie Blanchet
Sylvie Vuillermoz
Christophe Pison
François Arbib
Vincent Bonneterre
Dominique Valeyre
Olivia Freynet
Jean-François Mornex
Yves Pacheco
Nathalie Freymond
Françoise Thivolet
Marianne Kambouchner
Jean-François Bernaudin
Audrey Nathalizio
Pierre Pradat
Paul-André Rosental
Michel Vincent

Keywords

Sarcoidosis, dust exposure, bronchoalveolar lavage

Abstract

Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composition of inorganic particles was determined by energy-dispersive X-ray (EDX) spectroscopy. Dust exposure was also assessed by a specific questionnaire. Eight sarcoidosis patients and five healthy volunteers had a high dust load in their BAL. No significant difference was observed between the overall inorganic particle load of each group while a significant higher load for steel was observed in sarcoidosis patients (p=0.029). Moreover, the building activity sub-score was significantly higher in sarcoidosis patients (p=0.018). These results suggest that building work could be a risk factor for sarcoidosis which could be considered at least in some cases as a granulomatosis caused by airborne inorganic dust. The questionnaire should be validated in larger studies.

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