The Relationship Between Disease Severity and Hematologic Parameters in Geriatric Patients with Acute Pancreatitis

Main Article Content

Erhan Onalan
Yusuf Gökalp
Burkay Yakar

Keywords

Acute pancreatitis, Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, inflammatory marker.

Abstract

Background: Acute pancreatitis (AP) is an emergency disease within the field of internal diseases. Its
prevalence in the older population has been increasing in parallel to the increase in the older population. Objectives: This study aims to demonstrate the relationship of the platelet/lymphocyte ratio (PLR) and the neutrophil/ lymphocyte ratio (NLR), which were shown to be markers related to systemic inflammation, with Ranson criteria, which indicate the severity of acute pancreatitis at the time of admission, in geriatric (65 years and above) and non-geriatric (age<65 years) patients. Methods: Data from patients with acute pancreatitis who presented to the Internal Medicine Polyclinic at Firat University Medical Faculty Hospital between March 2015- September 2018 were retrospectively evaluated. Results: Platelet/lymphocyte ratio and neutrophil/lymphocyteratio were determined to be positively correlated with CRP, BUN, and WBC among Ranson criteria at the time of admission (respectively; P<0.001; P<0.001; P<0.05). Based on the results of linear regression analysis, we found that neutrophil/lymphocyteratio and platelet/lymphocyte ratio were independent predictors of acute pancreatitis severity. Conclusion: PLR and NLR, which indicate systemic inflammation, can be used as simple and reliable markers to determine acute pancreatitis severity, and can be used more specifically in the geriatric age group.


 

Abstract 231 | PDF Downloads 157

References

- Yalçın S, Kanatlı MÇ. İntestinal mikrobiyota transplantasyonu; neden, kime, nasıl? Pamukkale Tıp Dergisi 2015; 8 (1): 148-154.
2- Nazlıkul H. Duygusal beyin: Bağırsak. İstanbul, Destek Yayınları 2018; 15-147.
3-Mayer E. Beyin-Bağırsak Bağlantısı (Üçüncü Baskı). İstanbul: Paloma Yayınevi 2017; 24-52.
4- Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatric Clinics, 2013; 60 (1): 49-74.
5- Junger A. Temiz bağırsak. İstanbul: Pegasus Yayınları 2018; 30-92.
6- Perlmutter D, Loberg K. Beyin ve bağırsak (Birinci Baskı). İstanbul: Pegasus Yayınları 2017; 15-125.
7- Murray PR. Temel tıbbi mikrobiyoloji. Ankara: Güneş Tıp Kitabevleri 2018; 40-146.
8-Stojanovic MR, Vos WM. The first 1000 cultured species of the human gastrointestinal microbiota. FEMS Microbiology Reviews 2014; 38: 996–1047.
9-Özdemir A, Demirel ZB. Beslenme ve mikrobiyota ilişkisi. Journal of Biotechnology and Strategic Health Research 2017; 1: 25-33.
10-Yatsunenko T, Rey FE, Manary MJ, Trehan I, Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone A, Lauber C, Clemente CJ, Knights D, Knight R, Gordon JI. Human gut microbiome viewed across age and geography. Nature 2012; 486(7402): 222-227.
11-Filippo DC, Cavalieri D, Paola MD, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences 2010; 107(33): 14691-14696.


12- Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut. 2009; 58(8): 1091-103.
13-Legarrea-Lopez P, Fuller NR, Zulet MA, Martinez JA, Caterson ID. The influence of Mediterranean, carbohydrate and high protein diets on gut microbiota composition in the treatment of obesity and associated inflammatory state. Asia Pacific Journal of Clinical Nutrition 2014; 23(3): 360-368.
14-Tannock GV, Lawley B, Munro K, Pathmanathan SG, Zhou SJ, Makrides M, Gibson RA, Sullivan T, Prosser CG, Lowry D, Hodgkinsong AJ. Comparison of the compositions of the stool microbiotas of infants fed goat milk formula, cow milk-based formula, or breast milk. Applied and Environmental Microbiology 2013; 79(9): 3040-3048.
15-Cerda B, Perez M, Pérez-Santiago JD, Tornero-Aguilera JF, González-Soltero R, Larrosa M. Gut Microbiota Modification: Another Piece in the Puzzle of the Benefits of Physical Exercises in Health? Frontiers in Physiology 2016; 7(51): 2-11.
16-Campbell S, Wisniewski PJ. Exercises is a novel promoter of intestinal health and microbial diversity. Exercise and Sports Sciences 2017; 45(1): 41-47.
17-Clarke SF, Murphy EF, O’Sullivan O, Lucey AC, Humphreys M, Hogan A, Hayes P, O’Reilly M, Jeffery IB, Wood-Martin R, Kerins DM, Quigley E, Ross RP, O’Toole PW, Molloy MG, Falvey E, Shanahan F, Cotter PD. Exercise and associated dietary extremes impact on gut microbial diversity. Gut 2014; 63: 1913–1920.
18-Barton W, Penney NC, Cronin O, Garcia-Perez I, Molloy MG, Holmes E, Shanahan F, Cotter PD, O’Sullivan O. The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level. Gut 2018; 67 (4): 625-633.
19-Mach N, Fuster-Botella D. Endurance exercise & gut microbiota: A review. Journal of Sport and Health Science 2017; 6(2): 179-197.
20-Hsu YJ, Huang WC, Lin JS, Chen YM, Ho ST, Huang CC, Tung YT. Kefir supplementation modifies gut microbiota composition, reduces physical fatigue, and improves exercise performance in mice. Nutrients 2018; 10(7): 862.
21-Monda V, Villaono I, Messina A, Valenzano A, Esposito T, Moscatelli F, Viggiano A, Cibelli G, Chieffi S, Monda M, Messina G. Exercise modifies the gut microbiota with positive health effects. Oxidative Medicine and Cellular Longevity 2017;1-8.
22-Taniguchi H, Tanisawa K, Sun X, Kobo T, Hoshino Y, Hosokawa M, Takeyama H, Higuchi M. Effects of short-term endurance exercise on gut microbiota in elderly men. Physiol Rep 2018; 6 (23): 1-15.
23-Codella R, Luzi L, Terruzzi I. Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases. Digestive and Liver Disease 2018; 50(4): 331-341.
24-Queipo-Ortuno MI, Seoane LM, Murri M, Pardo M, Gomez-Zumaquero JM, Cardona F, Casanueva F, Tinahones FJ. Gut microbiota composition in male rat models under different nutritionalstatus and physical activity and its association with serum leptin and ghrelin levels. PLoS ONE 2013; 28;8(5): e65465.
25-Chaves FM, Baptista IL, Simabuco FM, Quaresma PGF, Pena FL, Bezerra RMN, Pauli JR, Cunha DT, Campos-Ferraz PL, Antunes AEC. High-intensity-exercise-induced intestinal damage is protected by fermented milk supplemented with whey protein, probiotic and pomegranate (Punica granatum L.). British Journal of Nutrition 2018; 119 (8): 896–909.
26-Matsumoto M, Inoue R, Tsukahara T, Ushida K, Chiji H, Matsubara N, Hara H. Voluntary running exercise alters microbiota composition and increases n-butyrate concentration in the rat cecum. Biosci. Biotechnol. Biochem. 2008; 72(2): 572-576.
27-Chen J, Guo Y, Gui Y, Xu D. Physical exercise, gut, gut microbiota, and atherosclerotic cardiovascular diseases. Lipids in Health and Disease 2018;17(17): 1-7.
28-Liu Z, Liu HY, Zhou H, Zhan Q, Lai1 W, Zeng Q, Ren H, Xu D. Moderate-intensity exercise affects gut microbiome composition and influences cardiac function in myocardial infarction mice. Frontiers in Microbiology 2017; 8: 1687.
29-Batacan RB, Fenning AS, Dalbo VJ, Scanlan AT, Duncan MJ, Moore RJ, Stanley D. A gut reaction: the combined influence of exercise and diet on gastrointestinal microbiota in rats. Journal of Applied Microbiology 2017; 122(6): 1627-1638.
30-Mujico JR, Baccan GY, Gheorghe A, Diaz LE, Marcos A. Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice. British Journal of Nutrition 2013; 110(4): 711-720.
31-Busnelli M, Manzini S, Sirtori CR, Chiesa G, Parolini C. Effects of vegetable proteins on hypercholesterolemia and gut microbiota modulation. Nutrients 2018; 10(9): 1249.
32-Zheng W, Wang K, Sun Y, Kuo SM. Dietary or supplemental fermentable fiber intake reduces the presence of Clostridium XI in mouse intestinal microbiota: The importance of higher fecal bacterial load anddensity. PLOS ONE 2018; 13(10): 1-17.