The relationship between neutrophil lymphocyte ratio and 28-day mortality in intensive care patients

Main Article Content

Hamit Yildiz

Keywords

Neutrophil to lymphocyte ratio, sepsis, intensive care, 28-day mortality

Abstract

The aim of this study is to investigate the relationship between neutrophil to lymphocyte ratio (NLR) at admission to ICU and 28-day mortality in patients with sepsis and septic shock, which is an important cause of mortality in the intensive care unit (ICU). Data of consecutive 398 patients with sepsis and septic shock who interned to ICU were retrospectively reviewed and included in the study. NLR, 28-day mortality and other laboratory datas were collected retrospectively from the ICU archive. 111(27.89%) patients died within 28 days after admission to ICU. NLR was higher in patients with sepsis group (p:0.01). However, 28-day mortality was higher in septic shock group (p<0.001). There was no significant relationship between NLR at admission to ICU and 28-day mortality (p>0.05). Patients with sepsis admited to ICU were found to have higher NLR at admission. This study supports that NLR at admission has no effect on 28-day mortality.

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References

1. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N. Eng J Med 1999;340:207-14
2. Heyland DK, Hopman V, Coo H, et al. Long-term health related quality of life in survivors of sepsis. Crit Care Med 2009;289:3599-605
3. Bone RC, Balk RA, Cerra FB, et al. American Collage of Chest Physicians Society of Critical Care Medicine Concensus Conference: Definitions for sepsis and organ failure and guideliens fort he use innovative therapies in sepsis. Crit Care Med. 1992;20:864-874.
4. Hotchkiss RS., Karl JE. The pathophysiology and treatment of sepsis. N Eng J Medicine 2003;3482:138-150.
5. Salvo I, Cian W., Musicco M., et al. The sepsis study group. The Italian sepsis stufy:priliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock. Intensive Care Med. 1995;21:244-249
6. Muckart DJJ, Bhagwanjee S. American Collage of Physicians/Society of Critical Care Medicine Concensus Conference: definition of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients. Crit Care Med 1997;25:1789-1795
7. Buyukkaya E, Karakas MF, Karakas E, et al. Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic sundrome. Clin Appl Thromb Hemost 2014;20:159-63
8. Turkmen K, Erdur Fm, Ozcicek F, et al. Platelet-lymphocyte ratio better predicts inflammation than neutrohil-lymphocyte ratio in end-stage renal disease patients. Hemodial Int 2013;17:391-6
9. Imtiaz F, Shafique K, Mirza SS, et al. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012;5:2.
10. Kawczynski P, Piotrowski A. Procalcitonin and C-reactive protein as a markers of neonatal sepsis. Ginekol Pol 2004;75:439-44
11. Zahorec R. Ratio of neutrophil to lymhocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratislavske Lekarse Listy, vol.102, no.1, pp. 5-14,2001.
12. Kang MH, Go SI, Song HN. The prognostic impact of the neutrophil to lymphocyte ratio in patients with small cell lung cancer. British Journal of Cancer, vol. 111, no.3, pp. 452-460,2014.
13. Ayça B, Akln F, Celik O, et al. Neutrphil to lymphocyte tario is related to stent thrombosis and high mortality in patients with acute myocardial infarction. Angiology, vol. 66, no. 6, pp. 545-552,2015.
14. Makino I, Tajima H, Kitagawa H, et al. A case of severe sepsis presenting marked decrease of neutrophils and interesting finsings on dynamic CT. Am J Care Rep. 2015; 16: 322-327.
15. Salciccioli JD, Marshall DC, Pimentel MA, et al. The association between the neutrophil to lmphocyte ratio and mortality in critical illness: an observational cohort study. Crit Care 2015;19:13
16. Riche F, Gayat E, Barthelemy R, et al. Reversal of neutrophil-to-lymphocyte count ratio in early versus late death from septic shock. Crit Care 2015;19:439
17. Akilli NB, Yortanli M, Mutlu H, et al. Prognostic importance of neutrophil-lymphocyte ratio in critically ill patients: short- and long-term outcomes. Am J Emerg Med 2014;32:1476-80

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