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C-reactive protein, diabetes, inflammation, obesity, waist circumference
Background/Aim: High sensitivity C-reactive protein (hsCRP) in widely recognized inflammation marker associated with increased cardiovascular disease (CVD) risk. Since CVD is a common complication in type 2 diabetes (DM2), and since there is a high prevalence of population with obesity and DM2 in Montenegro, we aimed to examine the association of hsCRP with anthropometric and metabolic parameters in the cohort of individuals with DM2.
Methods: A total of 184 participants with DM2 (of them 47.3% females) were recruited in this cross-sectional study. Fasting glucose, glycated hemoglobin, lipid parameters and hsCRP were measured. Anthropometric parameters were obtained. Participants were stratified into low (hsCRP <1 mg/L), intermediate (1 mg/L≤ hsCRP <3 mg/L) and high risk CVD category subgroup (hsCRP ≥3 mg/L).
Results: Significantly higher number of females were in the high hsCRP subgroup, compared with males (χ2=12.80, p<0.001). Also, significantly higher number of obese individuals were in the high risk subgroup compared with low risk subgroup (χ2= 18.68, p<0.001). Multiple linear regression analysis showed that waist circumference (WC) (Beta=0.205, p=0.045) and glucose (Beta=0.305, p=0.003) in males, and WC in females (Beta=0.405, p=0.003), were the independent predictors of hsCRP levels.
Conclusion: Unlike some other anthropometric indices, WC is independently associated with hsCRP, suggesting that this simple parameter could be a reliable and cost-effective tool for evaluating CVD risk in population with DM2.