Raw red onion intake and insulin resistance markers in overweight or obese patients with polycystic ovary syndrome: a randomized controlled-clinical trial

Main Article Content

Mehranghiz Ebrahimi-Mameghani
Maryam Saghafi-Asl
Mitra Niafar
Mohammad Asghari-Jafarabadi
Mehran Mesgari-Abbasi


Polycystic ovary syndrome, Insulin resistance, Onion, Diet, Body mass index


Background: Insulin resistance (IR) plays a pivotal role in the development of polycystic ovary syndrome (PCOS). Though hypoglycemic and hypolipidemic effects of onion have been suggested in type 2 diabetes mellitus, still, lack of data exist to investigate its hypoglycemic effect in PCOS. Objective: to assess the effects of raw red onion consumption on IR markers in PCOS. Methods: In this randomized controlled-clinical trial, 53 overweight or obese non-diabetic patients with PCOS were randomly allocated to either group of high-onion (HO; raw red onions: 2×40-50 g/day for overweight and 2×50-60 g/day for obese patients) or low-onion (LO; raw red onions: 2×10-15 g/day) for an 8 weeks. Fasting and 2-hour blood sugar, insulin, total testosterone, and progesterone, as well as homeostasis model of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) were measured at baseline and after treatment. IR was defined as HOMA-IR≥3.8 in PCOS. Anthropometric indices and dietary intake were also evaluated. Results: After 8 weeks, no differences were observed in the IR markers including HOMA-IR neither within nor between the HO (from 3.53±1.22 to 4.08±1.70; P=0.090) and LO groups (from 3.58±1.75 to 3.32±1.36; P=0.338). Anthropometric and dietary parameters did not differ between the two groups (P>0.050). However, a non-significant increase was observed in the rate of menses occurrence in HO (17%) compared to LO group (6%) after 8 weeks. Conclusions: Although raw red onion intake could not significantly improve IR markers in non-diabetic patients with PCOS, it could increase the chance of menses occurrence. Further investigations are warranted to determine the effects of onion in these patients.


Download data is not yet available.
Abstract 1 | PDF Downloads 12