Transaminases and celiac disease: a relationship to be reassessed

Main Article Content

Maurizio Mennini
Federica Ferrari
Michele Valente
Giulia D'Amati
Salvatore Cucchiara

Keywords

Celiac Disease, transaminases, liver biopsy, hypertransaminasemia, gluten-free diet

Abstract

Celiac Disease is a permanent intolerance to ingested gluten. The occurrence of liver impairment in CD is well described and can be regarded as one of the mainfold extra intestinal presentations of gluten-sensitive enteropathy. This increase is always mild or moderate, up to 5 times the upper limit of normal and transaminases decrease to normal range in most of patients on Gluten-free diet in maximum 12 months. We describe the case of a 16 months male addressed to our Operative Unit because of chronic diarrhea and poor weight growth with a severe increase of transaminases without a possible explanation. The case of our patient has highlighted the possibility of very high aminotransferase levels (up to 17 times the upper level normal of ALT) with a very slow decrease on a Gluten-free diet. It is necessary to study liver function in children at CD diagnosis and to seek celiac disease also in cases of severe hypertransaminasemia of unknown cause.

Downloads

Download data is not yet available.
Abstract 307 | PDF Downloads 63