Celiac Disease is a permanent intolerance to ingested gluten. The occurrence of liver impairment in CD is well described and can be regarded as one of the mainfold extra intestinal presentations of gluten-sensitive enteropathy. This increase is always mild or moderate, up to 5 times the upper limit of normal and transaminases decrease to normal range in most of patients on Gluten-free diet in maximum 12 months. We describe the case of a 16 months male addressed to our Operative Unit because of chronic diarrhea and poor weight growth with a severe increase of transaminases without a possible explanation. The case of our patient has highlighted the possibility of very high aminotransferase levels (up to 17 times the upper level normal of ALT) with a very slow decrease on a Gluten-free diet. It is necessary to study liver function in children at CD diagnosis and to seek celiac disease also in cases of severe hypertransaminasemia of unknown cause.
Mennini M, Ferrari F, Valente M, D’Amati G, Cucchiara S. Transaminases and celiac disease: a relationship to be reassessed. Progr Nutr [Internet]. 2016Jun.17 [cited 2019Sep.21];18(2):190-2. Available from: http://mattioli1885journals.com/index.php/progressinnutrition/article/view/4949
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Maurizio Mennini, Department of Pediatrics, "Sapienza" University of Rome
Federica Ferrari, Department of Pediatrics, "Sapienza" University of Rome
Michele Valente, Department of Radiological Oncological and Pathological Sciences, “Sapienza” University of Rome
Giulia D'Amati, Department of Radiological Oncological and Pathological Sciences, “Sapienza” University of Rome
Salvatore Cucchiara, Department of Pediatrics, "Sapienza" University of Rome