Brain-derived neurotrophic factor in obese women and its relationship with leptin and ghrelin

Sorayya Kheirouri, Shirin Haghighi, Atoosa Saidpour


Objectives: We aimed to assess the brain-derived neurotrophic factor (BDNF) level and its relation with leptin and ghrelin levels in obese women. Methods: In this case-control cross-sectional study, forty obese women and 40 healthy normal weight women aged (20- 50 y) were participated. Anthropometric indices were measured and serum levels of BDNF, leptin and ghrelin were assessed by the ELISA method. Results: Obese women had significantly higher leptin, but lower ghrelin levels compared with normal weight women. BDNF level was comparable between the two groups of women. There was a strong positive correlation between leptin and anthropometric parameters. A significant negative association was found between BDNF and leptin levels in normal weight women (r= -0.41, p= 0.02). Conclusion: Our results in women do not support a relationship between BDNF and obesity. Anthropometric indices may be important predictors of the leptin level. Further studies are required to elucidate the exact link between BDNF and leptin.


Obesity, BDNF, Leptin, Ghrelin

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DOI: 10.23751/pn.v19i2.4858

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ISSN: 1129-8723