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Polyunsatured fatty acids n-3, polyunsatured fatty acids n-6, steatosis, etiopathogenesis, therapy
Fatty acids are structural molecules of vegetable and animal lipids. Among this class our attention has been focused upon, omega 3 polyunsatured fatty acids (PUFA n-3) (Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and omega 6 polyunsatured fatty acids (PUFA n-6). They are synthetized by human cells only in small amounts, and an adequate nutritional intake is required. Fatty fishes, fish and vegetable oils are the most important sources of these compounds, but also some seaweeds supply PUFA n-3. Omega 3 have recently been addressed to prevention and management of and non-alcoholic fatty liver disease (NAFLD), specifically induced to obesity, insulin resistance, and high sugar and high saturated fatty acids diets. The current review analyzes an update of clinical studies of PUFA n-3and PUFA n-6 administration in NAFLD patients. In comparison we have reviewed the main NAFLD management behavioral strategies such as body weight reduction, diet modifications, supplementation and drugs therapy .