Case report of atypical endometrial stromal cells in an endometrial polyp and osteoclastic like giant cells in leiomyoma in the same patient: Is it a coincidence or is it a result of Tamoxifen treatment?

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Çiğdem Öztürk
Tuğçe Çay
Seza Tetikkurt
Emre Volkan Kasımogullar
Tolga Karacan

Keywords

atypical endometrial stromal  cells,, osteoclastic like giant cells, leiomyoma, tamoxifen treatment

Abstract

Atypical stromal cells are  rarely identified in the endometrial polyps of the female lower genital system. These cells are suggested to develop due to a degenerative or reactive phenomenon. And also osteoclastic like giant cells, which have been reported in numerous epithelial and mesenchymal tumours of uterus, may develop as a result of a degenerative or a reactive process. In this case report, we present a patient with breast cancer who was commenced on Tamoxifen treatment presenting with formation of  both atypical stromal cells in an endometrial polyp and osteoclastic like giant cells in the leiomyoma of the uterus. Patients who are treated with Tamoxifen should be followed meticulously to detect tumoral or proliferative lesions of endometrium and myometrium because of the adverse  effects of  tamoxifen on uterus.

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