An uncommon case of chronic myeloid leukemia with variant cytogenetic

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Mohamed A Abdullah
Aliaa Amer
Zafar Nawaz
Ali S Abdullah
Ahmad Al-Sabbagh
Samah Kohla
Abdulqadir J Nashwan
Mohamed A Yassin

Keywords

CML, variant cytogenetic, accelerated phase

Abstract

Chronic Myeloid Leukemia (CML) is myeloproliferative neoplasm characterized by Philadelphia chromosome which is a balanced translocation between chromosome 9 and 22 in 90% of cases. However, variant cytogenetic still happens in 5-10 % of cases, the importance of which is controversial as well as its response to therapy, prognosis and progression to acute leukemias. Here we report a male patient with CML and variant cytogenetic who responded to low dose of Dasatinib (50 mg daily).

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