An unusual case of hypopituitarism associated with non-small cell lung cancer

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Leyla Ozer
Mustafa Genco Erdem
Bedrettin Orhan
Ahmet Gulmez
Deccane Duzenci
Mustafa Canhoroz
Yusuf Ozkan
Hakan Artas


Hypopituitarism, non-small cell lung cancer, pituitary, metastasis, mucocele


Background: Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related death which can present with various clinical situations. Hypopituitarism when encountered with NSCLC may be due to diverse etiologies including pituitary metastasis, hypophysitis, pituitary infarction or a consequence of therapeutical interventions such as surgery or radiotherapy. Result: We present an unusual case of hypopituitarism in a NSCLC patient associated with a benign disorder, a sinus mucocele and thereby review the pathogenesis of hypopituitarism accompanying malignant diseases. Conclusion: Our case represents an example of association of a benign disorder with malignancy causing severe deterioration of life quality. Although rare, pituitary metastasis is the initial possible diagnosis in the setting of non-small cell lung cancer.
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